ABSTRACT
Introducción: La dermatitis atópica (DA) severa suele tener un componente psiquiátrico que puede influir en el desencadenamiento y exacerbación de los síntomas cutáneos. La neuroimagen funcional podría objetivar disfunciones neuronales existentes en estos pacientes.Objetivo: Investigar la presencia de trastornos de la perfusión cerebral en pacientes con DA severa y describir sus características mediante SPECT. Materiales y métodos: 11 pacientes adultos con DA severa fueron estudiados por evaluación psiquiátrica clínica y SPECT cerebral con 99mTc-ECD. Resultados: 90.3 por ciento de los pacientes presentaron un trastorno de ansiedad generalizada, 63.6 por ciento un trastorno obsesivo compulsivo y 63.6 por ciento depresión. Todos los pacientes presentaron trastornos de perfusión, que predominaron en la corteza prefrontal. Se evidenciaron alteraciones concordantes con los patrones descritos en pacientes que asocian síntomas depresivos y ansiosos. Conclusiones: Demostramos la presencia frecuente de alteraciones de la perfusión cerebral en la DA severa con componente psiquiátrico y describimos sus características mediante un método de neuroimagen.
Subject(s)
Male , Adolescent , Adult , Humans , Female , Middle Aged , Tomography, Emission-Computed, Single-Photon , Cerebrovascular Circulation/physiology , Organotechnetium Compounds , Dermatitis, Atopic/complications , Telencephalon , Mental Disorders , Mental Disorders/etiology , Depression/etiology , Precipitating Factors , Radiopharmaceuticals , Telencephalon/blood supply , Obsessive-Compulsive Disorder/etiology , Anxiety Disorders/etiologyABSTRACT
The origin of the blood supply to the brain and arteries of the ventral surface of the brain was studied in 31 adult chinchillas (Chinchilla lanigera). The arterial system was filled with latex 603 via the brachioencephalic trunk and the left subclavian artery, both of which arose from the aortic arch in most cases. The right and left internal carotid arteries (100% and 93.3%, respectively) did not contribute to the brain supply. The vertebral arteries were present in all cases and formed the basilar artery (96.7%) that gave off the ventral spinal artery caudally in all cases. The caudal cerebellar artery was single (80%) or double (20%) on the right, and single (70%) or double (30%) on the left. The rostral cerebellar artery was present as a caudal vessel on the right (73.3%) and on the left (70%), and as a rostral vessel in all cases. The rostral tectal artery was single in all cases. The caudal cerebral artery was single (53.3%), double (36.7%) or triple (10%) on the right, and single (46.7%), double (46.7%) or triple (6.7%) on the left. The hypophyseal artery was present in all cases. The internal ophthalmic artery was present only on the right (26.7%), or only on the left (23.3%). The middle cerebral artery was single in all cases on both sides. The rostral cerebral artery was present as a well-developed (96.7%) or vestigial (3.3%) vessel in both antimeres, gave off lateral arteries to the olfactory bulb and the median rostral inter-hemispheric artery, and ended as the internal ethmoidal artery. The cerebral arterial circle was open (70%) or closed (30%) rostrally, and closed caudally in all cases. The brain was supplied almost exclusively by the vertebral-basilar system.